Promoting access to treatment for patients with haemoglobin disorders

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چکیده ندارد.

Gene therapy: Repairing haemoglobin disorders with ribozymes

A ribozyme-mediated approach has made it possible to replace the region in beta globin mRNA containing the sickle-cell-anaemia mutation with a gamma-globin-encoding sequence. This is an interesting new way of correcting monogenic disease, but there are major problems to overcome before it could be applied in the clinic.

promoting access to White Rose

23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 Partial EVPI calculations can quantify the value of learning about particular subsets of uncertain parameters in decision models. Published case studies have used different computational approaches. This paper examines the computation of partial EVPI estimates via Monte-Carlo sampling algorithms. Our mathematical definition shows two nest...

promoting access to White Rose

Haemoglobin level and vascular access survival in haemodialysis patients.

BACKGROUND A full correction of anaemia in haemodialysis (HD) patients may lead to an increased risk of vascular access (VA) failure. We studied the relationship between haemoglobin (Hb) level and VA survival. METHODS Incident patients between January 2000 and December 2002 with <1 month on HD were considered. The relative risk (RR) of access failure was evaluated in four different groups of ...